Edward Bonnevie publishes two journal articles

Edward Bonnevie has published a paper in the journal Cartilage and a paper in the journal PLoS One.

 

Characterization of Tissue Response to Impact Loads Delivered Using a Hand-Held Instrument for Studying Articular Cartilage Injury

In this paper, we present a post-traumatic osteoarthritis model that utilizes a spring-loaded impacting device. We show that this device can provide controlled, repeatable insults to the surfaces of articular cartilage and determine mechanical thresholds around which surface cracking may occur in cartilage.

 

Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid

In this paper, we present a framework to more fully understand lubrication by synovial fluid macromolecules. Specifically, we found that two molecules, lubricin and hyaluronic acid, lubricate by distinct mechanisms but also act synergistically. Optimal cartilage lubrication is achieved when the boundary lubricant, lubricin, anchors to the cartilage surface and facilitates the aggregation of the viscous lubricant, hyaluronic acid.