Stephen Sloan Publishes an Article in Acta Biomaterialia

Stephen Sloan recently published an article in the journal Acta Biomaterialia entitled: Initial Investigation of Individual and Combined Annulus Fibrosus and Nucleus Pulposus Repair Ex Vivo.

 

Intervertebral disc degeneration affects an estimated 90% of individuals throughout their life, and is a candidate pathology for tissue engineered repair. The current standard of clinical care reduces spinal articulation and leads to further degeneration along the spine, hence great interest in a regenerative medicine therapy. Lit- erature studies focused on biomaterial repair strategies for treating degenerated discs have partially restored native disc function, however no studies have reported the use of combined therapies to address multiple aspects of disc degeneration. This initial investigation screened injectable biomaterial repair strategies ex vivo, and through complementary outcome measures showed a combined therapy restores disc function better than individual approaches. This study is the first of its kind to address multiple aspects of disc degeneration, using clinically-oriented biomaterials in a well-established animal model.

Nicole Diamantides Publishes a Paper in Biofabrication

Nicole Diamantides published a paper in Biofabrication entitled, Correlating rheological properties and printability of collagen bioinks: the effects of riboflavin photocrosslinking and pH.

Collagen has shown promise as a bioink for extrusion-based bioprinting, but further development of new collagen bioink formulations is necessary to improve their printability. The goal of this work was to determine the effects of riboflavin photocrosslinking and pH on collagen bioink rheology before, during, and after gelation and directly correlate these findings to the printability of each bioink formulation.  We found that riboflavin photocrosslinking and pH levels above physiologic resulted in improved collagen bioink printability and that printability was most strongly correlated with rheological properties of the bioink during extrusion.  These findings will allow for the more rapid screening of new collagen bioink formulations.

Christopher DiDomenico Publishes a Paper in the Journal of Biomechanical Engineering

Christopher DiDomenico published a paper in the Journal of Biomechanical Engineering entitled, “The Effect of Antibody Size and Mechanical Loading on Solute Diffusion through the Articular Surface of Cartilage.”

Due to the heterogeneous nature of articular cartilage tissue, penetration of potential therapeutic molecules for osteoarthritis (OA) through the articular surface is complex, with many factors that affect transport of these solutes within the tissue. Therefore, the goal of work is to investigate how the size of antibody variants, as well as application of cyclic mechanical loading, affect solute transport within healthy cartilage tissue. Ultimately, solutes of this size do not diffuse uniformly, nor are convected uniformly, through the depth of the cartilage tissue. This research potentially holds great clinical significance to discover ways of further optimizing transport into cartilage and lead to effective antibody-based treatments for OA.

Prof. Bonassar and Dr. Härtl Publish a Book on Intervertebral Disc Repair

Prof. Larry Bonassar and long-time collaborator Dr. Roger Härtl, Professor of Neurosurgery and Chief of Spinal Surgery at Weill Cornell Medical, are the editors of a newly published book titled “Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians.” The book summarizes current biologically based approaches to treatment of degenerative disc disease, including the development of biomaterials and engineered tissues for the repair and regeneration of soft tissues in the spine.  The book includes 21 chapters authored by more than 60 international experts in the fields of orthopaedics, neurosurgery, biomechanics, biomaterials, and tissue engineering. The book is published through Thieme Publishing (New York) and will be officially released on July 12, 2017.  Print and electronic copies can be ordered through Amazon.

Mary Clare McCorry Receives her PhD in Biomedical Engineering

Mary Clare McCorry passed her B Exam and received her PhD in Biomedical Engineering. Congrats, Mary Clare!

Alexander Boys Receives a Travel Award from at the ICCBMT

Alexander Boys received a ICCBMT Travel Award at the International Conference on the Chemistry and Biology of Mineralized Tissue (ICCBMT). Congrats, Alex!

Nicole Diamantides Receives her M.S. in Biomedical Engineering

Nicole Diamantides passed her A Exam and received her M.S. in Biomedical Engineering. Congrats, Nicole!

Jill Middendorf Receives her M.S. in Mechanical Engineering

Jill Middendorf passed her A Exam and received her M.S. in Mechanical Engineering. Congrats, Jill!

Dr. Jenny Puetzer Accepts Faculty Position at VCU

Bonassar Lab alum Dr. Jenny Puetzer has accepted a position as an Assistant Professor in the Department of Biomedical Engineering at Virginia Commonwealth University.  She received her PhD in Biomedical Engineering from Cornell in 2014 and is currently a Whitaker Foundation International Fellow in the laboratory of Prof. Molly Stevens in Imperial College, London.  She will finish her postdoctoral studies at the end of 2017 and begin her faculty position at VCU in January 2018. Congratulations, Jenny!

Benjamin Cohen Receives an Award for his Presentation at the TERMIS-AM 2016 Conference

Benjamin Cohen receives a Scientist Award for the TERMIS-AM 2016 Conference. Ben has received this award for his presentation entitled “Full-Scale Tissue Engineered Auricles through Auricular Chondrocyte-Mesenchymal Stem Cell Co-Implantation” discussing his research tissue engineering the human ear.

Congratulations, Ben!