Benjamin Cohen Publishes a Paper in the Annals of Plastic Surgery

Benjamin Cohen publishes a paper in the Annals of Plastic Surgery. The paper is entitled, Tissue Engineering Auricular Cartilage Using Late Passage Human Auricular Chondrocytes.

Auricular (ear) reconstruction is a challenging clinical procedure, and tissue engineering offers a superior technique to accurately and effectively replace a damaged or deformed auricle. A clinical biopsy of healthy ear cartilage can provide ~10 million auricular chondrocytes, however a full-sized pediatric ear requires at least 200 million cells to generate. Repeated passaging of chondrocytes to expand their number has been shown to limit the ability of the cells to produce new cartilage, however limited research exists regarding this process with auricular-specific chondrocytes. This paper examines the capacity for extensively expanded auricular chondrocytes to produce native-like auricular cartilage following implantation to determine the limit of potential chondrocyte expansion. We found that cells expanded as far as fifth passage were capable of generating robust auricular cartilage while also significantly increasing in number. This work indicates that a clinically relevant donor amount of cartilage has the potential to populate a full-sized ear construct, bringing us closer to the translation of tissue engineering as a method of auricular reconstruction.

Prof. Bonassar Interviewed by CNN

Prof. Bonassar was interviewed by CNN for his reaction to a recently published study about a clinical application of tissue engineered cartilage.  The story describes work in which researchers from China implanted tissue-engineered ears onto children with microtia, a congenital defect in which the external ear is malformed at birth.  The Bonassar lab has pioneered new techniques for manufacturing of engineered cartilage using techniques such as 3D printing and injection molding.  This new work paves the way for clinical trials of this technology in the near future.

Nicole Diamantides wins Cellink 3D Bioprinting Award at TERMIS meeting

Nicole Diamantides, a PhD student in Biomedical Engineering in the Bonassar Lab, won the Cellink 3D Bioprinting Award at the 2017 Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting in Charlotte, NC. Her paper, “The Effects of Adding Chondrocytes on the Printability of Collagen Bioinks for Cartilage Bioprinting,” investigated the effects of cell content on the rheology on collagen bioinks and how rheological parameters affects the printability of these inks.

This is the first annual 3D Bioprinting Award given a TERMIS.  The awards are based on scientific content, graphical design of the poster, and quality of presentation.  Congratulations to Nicole on her outstanding work and poster presentation!

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Stephen Sloan wins Presentation Award at PSRS

Stephen Sloan, a 3rd year PhD student in the Bonassar Lab, won a Trainee Podium award for Outstanding Scientific Research at the 4th International Spine Research Symposium. The presentation, entitled “Cell Delivery in Collagen Gels Enhances Annulus Fibrosus Repair of the Sheep Spine in Vivo,” describes the development of a new therapy for spinal disc herniation. The conference, held from October 23-26, 2017 in Lake Harmony, PA, brought together leaders in the field of spine research to understand degenerative diseases of the spine and to develop new treatments for spine degeneration. Co-authors on the paper were Prof. Bonassar and members of the laboratory of Dr. Roger Härtl, Chief of Spine Surgery at Weill Cornell Medical, Dr. Ibrahim Hussain, a resident in Neurosugery, and clinical research fellows Drs. Christoph Wipplinger, Gernot Lang, and Rodirgo Navarro-Rodriguez.  Congratulations to Stephen and the team for their outstanding work.