Publications

For a complete list, please visit PubMed.

Biologic Annulus Fibrosus Repair: A Review of Preclinical In Vivo Investigations. Sloan SR Jr, Lintz M, Hussain I, Härtl R, Bonassar LJ. Tissue Eng Part B Rev. 2017 Nov 4. doi: 10.1089/ten.TEB.2017.0351. [Epub ahead of print]

Degradation Alters the Lubrication of Articular Cartilage by High Viscosity, Hyaluronic Acid-Based Lubricants. Bonnevie ED, Galesso D, Secchieri C, Bonassar LJ. J Orthop Res. 2017 Oct 25. doi: 10.1002/jor.23782. [Epub ahead of print]

Total disc replacement using tissue-engineered intervertebral discs in the canine cervical spine. Moriguchi Y, Mojica-Santiago J, Grunert P, Pennicooke B, Berlin C, Khair T, Navarro-Ramirez R, Ricart Arbona RJ, Nguyen J, Härtl R, Bonassar LJ. PLoS One. 2017 Oct 20;12(10):e0185716. doi: 10.1371/journal.pone.0185716. eCollection 2017.

In vitro culture increases mechanical stability of human tissue engineered cartilage constructs by prevention of microscale scaffold buckling. Middendorf JM, Shortkroff S, Dugopolski C, Kennedy S, Siemiatkoski J, Bartell LR, Cohen I, BonassarLJ. J Biomech. 2017 Sep 14. pii: S0021-9290(17)30463-3. doi: 10.1016/j.jbiomech.2017.09.007. [Epub ahead of print]

Three-Dimensional Bioprinting and Its Potential in the Field of Articular Cartilage Regeneration. Mouser VHM, Levato R, Bonassar LJ, D’Lima DD, Grande DA, Klein TJ, Saris DBF, Zenobi-Wong M, Gawlitta D, Malda J. Cartilage. 2017 Oct;8(4):327-340. doi: 10.1177/1947603516665445. Epub 2016 Sep 1.

Annulus Fibrosus Repair Using High-Density Collagen Gel: An In vivo Ovine Model. Pennicooke B, Hussain I, Berlin C, Sloan SR, Borde B, Moriguchi Y, Lang G, Navarro-Ramirez R, Cheetham J, Bonassar LJ, Härtl R. Spine (Phila Pa 1976). 2017 Jul 17. doi: 10.1097/BRS.0000000000002334. [Epub ahead of print]

Synergistic Interactions of a Synthetic Lubricin-Mimetic with Fibronectin for Enhanced Wear Protection. Andresen Eguiluz RC, Cook SG, Tan M, Brown CN, Pacifici NJ, Samak MS, Bonassar LJ, Putnam D, Gourdon D. Front Bioeng Biotechnol. 2017 Jun 28;5:36. doi: 10.3389/fbioe.2017.00036. eCollection 2017.

Mitochondrial dysfunction is an acute response of articular chondrocytes to mechanical injury. Delco ML, Bonnevie ED, Bonassar LJ, Fortier LA. J Orthop Res. 2017 Jul 11. doi: 10.1002/jor.23651. [Epub ahead of print]

Correlating rheological properties and printability of collagen bioinks: the effects of riboflavin photocrosslinking and pH. Diamantides N, Wang L, Pruiksma T, Siemiatkoski J, Dugopolski C, Shortkroff S, Kennedy S, Bonassar LJ. Biofabrication. 2017 Jul 5;9(3):034102. doi: 10.1088/1758-5090/aa780f.

The Effect of Antibody Size and Mechanical Loading on Solute Diffusion Through the Articular Surface of Cartilage. DiDomenico CD, Goodearl A, Yarilina A, Sun V, Mitra S, Sterman AS, Bonassar LJ. J Biomech Eng. 2017 Sep 1;139(9). doi: 10.1115/1.4037202.

Initial investigation of individual and combined annulus fibrosus and nucleus pulposus repair ex vivo. Sloan SR Jr, Galesso D, Secchieri C, Berlin C, Hartl R, Bonassar LJ. Acta Biomater. 2017 Sep 1;59:192-199. doi: 10.1016/j.actbio.2017.06.045. Epub 2017 Jun 29.

Degenerative changes of the canine cervical spine after discectomy procedures, an in vivo study. Grunert P, Moriguchi Y, Grossbard BP, Ricart Arbona RJ, Bonassar LJ, Härtl R. BMC Vet Res. 2017 Jun 23;13(1):193. doi: 10.1186/s12917-017-1105-5.

Customized biomaterials to augment chondrocyte gene therapy. Aguilar IN, Trippel S, Shi S, Bonassar LJ. Acta Biomater. 2017 Apr 15;53:260-267. doi: 10.1016/j.actbio.2017.02.008. Epub 2017 Feb 7.

Mechanical properties and structure-function relationships of human chondrocyte-seeded cartilage constructs after in vitro culture. Middendorf JM, Griffin DJ, Shortkroff S, Dugopolski C, Kennedy S, Siemiatkoski J, Cohen I, BonassarLJ. J Orthop Res. 2017 Feb 7. doi: 10.1002/jor.23535. [Epub ahead of print]

Sub-critical impact inhibits the lubricating mechanisms of articular cartilage. Bonnevie ED, Delco ML, Galesso D, Secchieri C, Fortier LA, Bonassar LJ. J Biomech. 2017 Feb 28;53:64-70. doi: 10.1016/j.jbiomech.2016.12.034. Epub 2016 Dec 29.

Matrix stiffening promotes a tumor vasculature phenotype. Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA. Proc Natl Acad Sci U S A. 2016 Dec 29. pii: 201613855. doi: 10.1073/pnas.1613855114. [Epub ahead of print]

A Model System for Developing a Tissue Engineered Meniscal Enthesis. McCorry MC, Mansfield MM, Sha X, Coppola DJ, Lee JW, Bonassar LJ. Acta Biomater. 2016 Oct 28. pii: S1742-7061(16)30582-7. doi: 10.1016/j.actbio.2016.10.040. [Epub ahead of print]

Fiber Development and Matrix Production in Tissue Engineered Menisci using Bovine Mesenchymal Stem Cells and Fibrochondrocytes. McCorry MC, Bonassar LJ. Connect Tissue Res. 2016 Dec 7. [Epub ahead of print]

Optimizing cell sourcing for clinical translation of tissue engineered ears. Morrison KA, Cohen BP, Asanbe O, Dong X, Harper A, Bonassar LJ, Spector JA. Biofabrication. 2016 Dec 5;9(1):015004.

Hypoxic Expansion of Human Mesenchymal Stem Cells Enhances 3D Maturation of Tissue Engineered Intervertebral Discs. Hudson KD, Bonassar LJ. Tissue Eng Part A. 2016 Nov 30. [Epub ahead of print]

Cyclic Mechanical Loading Enhances Transport of Antibodies Into Articular Cartilage. DiDomenico CD, Xiang Wang Z, Bonassar LJ. J Biomech Eng. 2017 Jan 1;139(1). doi: 10.1115/1.4035265.

Human talar and femoral cartilage have distinct mechanical properties near the articular surface. Henak CR, Ross KA, Bonnevie ED, Fortier LA, Cohen I, Kennedy JG, Bonassar LJ. J Biomech. 2016 Oct 3;49(14):3320-3327. doi: 10.1016/j.jbiomech.2016.08.016.

Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches. Delco ML, Kennedy JG, Bonassar LJ, Fortier LA. J Orthop Res. 2016 Oct 20. doi: 10.1002/jor.23462. [Epub ahead of print] Review.

Human talar and femoral cartilage have distinct mechanical properties near the articular surface. Henak CR, Ross KA, Bonnevie ED, Fortier LA, Cohen I, Kennedy JG, Bonassar LJ. J Biomech. 2016 Aug 24. pii: S0021-9290(16)30901-0. doi: 10.1016/j.jbiomech.2016.08.016.

Biological Treatment Approaches for Degenerative Disk Disease: A Literature Review of In Vivo Animal and Clinical Data. Moriguchi Y, Alimi M, Khair T, Manolarakis G, Berlin C, Bonassar LJ, Härtl R. Global Spine J. 2016 Aug;6(5):497-518. doi: 10.1055/s-0036-1571955. Epub 2016 Jan 27. Review.

Binding and lubrication of biomimetic boundary lubricants on articular cartilage. Samaroo KJ, Tan M, Putnam D, Bonassar LJ. J Orthop Res. 2016 Jul 15. doi: 10.1002/jor.23370. [Epub ahead of print]

Hyaline Articular Matrix Formed by Dynamic Self-Regenerating Cartilage and Hydrogels. Meppelink AM, Zhao X, Griffin DJ, Erali R, Gill TJ, Bonassar LJ, Redmond RW, Randolph MA. Tissue Eng Part A. 2016 Jul;22(13-14):962-70. doi: 10.1089/ten.TEA.2015.0577. Epub 2016 Jul 7.

Physiologically Distributed Loading Patterns Drive the Formation of Zonally Organized Collagen Structures in Tissue-Engineered Meniscus. Puetzer JL, Bonassar LJ. Tissue Eng Part A2016 Jul;22(13-14):907-16. doi: 10.1089/ten.TEA.2015.0519. Epub 2016 Jun 27.

The effect of hypoxia on thermosensitive poly(N-vinylcaprolactam) hydrogels with tunable mechanical integrity for cartilage tissue engineering. Lynch B, Crawford K, Baruti O, Abdulahad A, Webster M, Puetzer J, Ryu C, Bonassar LJ, Mendenhall J. J Biomed Mater Res B Appl Biomater. 2016 May 30. doi: 10.1002/jbm.b.33705.

Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage. Reesink HL, Bonnevie ED, Liu S, Shurer CR, Hollander MJ, Bonassar LJ, Nixon AJ. Sci Rep. 2016 May 9;6:25463. doi: 10.1038/srep25463.

Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance. McCorry MC, Puetzer JL, Bonassar LJ. Stem Cell Res Ther. 2016 Mar 12;7(1):39. doi: 10.1186/s13287-016-0301-8.

Long-Term Morphological and Microarchitectural Stability of Tissue-Engineered, Patient-Specific Auricles In Vivo. Cohen BP, Hooper RC, Puetzer JL, Nordberg R, Asanbe O, Hernandez KA, Spector JA, Bonassar LJ. Tissue Eng Part A. 2016 Mar 14. [Epub ahead of print]

Biomechanical and biochemical characterization of porcine tracheal cartilage. Hoffman B, Martin M, Brown BN, Bonassar LJ, Cheetham J. Laryngoscope. 2016 Jan 30. doi: 10.1002/lary.25861. [Epub ahead of print]

Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid. Bonnevie ED, Galesso D, Secchieri C, Cohen I, Bonassar LJ. PLoS One. 2015 Nov 24;10(11):e0143415. doi: 10.1371/journal.pone.0143415. eCollection 2015.

Comparison of Efficacy of Endogenous and Exogenous IGF-I in Stimulating Matrix Production in Neonatal and Mature Chondrocytes. Aguilar IN, Trippel SB, Shi S, Bonassar LJ. Cartilage. 2015 Jun 11. doi: 10.1177/1947603515578691.

Mechanical properties and structure-function relationships in articular cartilage repaired using IGF-I gene-enhanced chondrocytes. Griffin DJ, Ortved KF, Nixon AJ, Bonassar LJ. J Orthop Res. 2015 Aug 26. doi: 10.1002/jor.23038. [Epub ahead of print]

Fibronectin mediates enhanced wear protection of lubricin during shear. Andresen Eguiluz RC, Cook SG, Brown CN, Wu F, Pacifici NJ, Bonassar LJ, Gourdon D. Biomacromolecules. 2015 Aug 6. [Epub ahead of print]

Measuring microscale strain fields in articular cartilage during rapid impact reveals thresholds for chondrocyte death and a protective role for the superficial layer. Bartell LR, Fortier LA, Bonassar LJ, Cohen I. J Biomech. 2015 Jun 12. pii: S0021-9290(15)00325-5. doi: 10.1016/j.jbiomech.2015.05.035. [Epub ahead of print]

Cell and protein compatible 3D bioprinting of mechanically strong constructs for bone repair. Sawkins MJ, Mistry P, Brown BN, Shakesheff KM, Bonassar LJ, Yang J. Biofabrication. 2015 Jul 2;7(3):035004. doi: 10.1088/1758-5090/7/3/035004.

Riboflavin crosslinked high-density collagen gel for the repair of annular defects in intervertebral discs: An in vivo study. Grunert P, Borde BH, Towne SB, Moriguchi Y, Hudson KD, Bonassar LJ, Härtl R. Acta Biomater. 2015 Jun 23. pii: S1742-7061(15)00271-8. doi: 10.1016/j.actbio.2015.06.006. [Epub ahead of print]

Mechanical Characterization of Matrix-Induced Autologous Chondrocyte Implantation (MACI®) Grafts in an Equine Model at 53 weeks. Griffin D, Bonnevie E, Lachowsky D, Hart J, Sparks H, Moran N, Matthews G, Nixon A, Cohen I, and Bonassar LJ,  J. Biomech., 2015 Apr 15. [Accepted Manuscript]

Induction of fiber alignment and mechanical anisotropy in tissue engineered menisci with mechanical anchoring. Puetzer JL, Koo E, Bonassar LJ. J Biomech. 2015 Feb 26. pii: S0021-9290(15)00123-2. doi: 10.1016/j.jbiomech.2015.02.033. [Epub ahead of print]

Joint-dependent response to impact and implications for post-traumatic osteoarthritis. Novakofski KD, Berg LC, Bronzini I, Bonnevie ED, Poland SG, Bonassar LJ, Fortier LA. Osteoarthritis Cartilage. 2015 Feb 26. pii: S1063-4584(15)00067-9. doi: 10.1016/j.joca.2015.02.023. [Epub ahead of print]

Dose-dependent response of tissue-engineered intervertebral discs to dynamic unconfined compressive loading. Hudson KD, Mozia RI, Bonassar LJ. Tissue Eng Part A. 2015 Feb;21(3-4):564-72. doi: 10.1089/ten.TEA.2014.0174. Epub 2015 Jan 19.

Injectable, high-density collagen gels for annulus fibrosus repair: An in vitro rat tail model. Borde B, Grunert P, Härtl R, Bonassar LJ. J Biomed Mater Res A. 2014 Dec 11. doi: 10.1002/jbm.a.35388. [Epub ahead of print]

Effects of enzymatic treatments on the depth-dependent viscoelastic shear properties of articular cartilage. Griffin DJ, Vicari J, Buckley MR, Silverberg JL, Cohen I, Bonassar LJ. J Orthop Res. 2014 Dec;32(12):1652-7. doi: 10.1002/jor.22713. Epub 2014 Sep 5.

Structure-function relations and rigidity percolation in the shear properties of articular cartilage. Silverberg JL, Barrett AR, Das M, Petersen PB, Bonassar LJ, Cohen I. Biophys J. 2014 Oct 7;107(7):1721-30. doi: 10.1016/j.bpj.2014.08.011.

Adhesion and integration of tissue engineered cartilage to porous polyethylene for composite ear reconstruction. O’Sullivan NA, Kobayashi S, Ranka MP, Zaleski KL, Yaremchuk MJ, Bonassar LJ, Randolph MA. J Biomed Mater Res B Appl Biomater. 2014 Sep 6. doi: 10.1002/jbm.b.33269. [Epub ahead of print]

Enhanced boundary lubrication properties of engineered menisci by lubricin localization with insulin-like growth factor I treatment. Bonnevie ED, Puetzer JL, Bonassar LJ. J Biomech. 2014 Jun 27;47(9):2183-8. doi: 10.1016/j.jbiomech.2013.10.028. Epub 2013 Oct 22.

Computed tomography-guided tissue engineering of upper airway cartilage. Brown BN, Siebenlist NJ, Cheetham J, Ducharme NG, Rawlinson JJ, Bonassar LJ. Tissue Eng Part C Methods. 2014 Jun;20(6):506-13. doi: 10.1089/ten.TEC.2013.0216. Epub 2013 Dec 11.

Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine. Grunert P, Gebhard HH, Bowles RD, James AR, Potter HG, Macielak M, Hudson KD, Alimi M, Ballon DJ, Aronowitz E, Tsiouris AJ, Bonassar LJ, Härtl R. J Neurosurg Spine. 2014 Apr;20(4):443-51. doi: 10.3171/2013.12.SPINE13112. Epub 2014 Feb 14.

Assessment of intervertebral disc degeneration based on quantitative magnetic resonance imaging analysis: an in vivo study. Grunert P, Hudson KD, Macielak MR, Aronowitz E, Borde BH, Alimi M, Njoku I, Ballon D, Tsiouris AJ, Bonassar LJ, Härtl R. Spine (Phila Pa 1976). 2014 Mar 15;39(6):E369-78. doi: 10.1097/BRS.0000000000000194.

Identification of cartilage injury using quantitative multiphoton microscopy. Novakofski KD, Williams RM, Fortier LA, Mohammed HO, Zipfel WR, Bonassar LJ. Osteoarthritis Cartilage. 2014 Feb;22(2):355-62. doi: 10.1016/j.joca.2013.10.008. Epub 2013 Nov 1.

Annular repair using high-density collagen gel: a rat-tail in vivo model. Grunert P, Borde BH, Hudson KD, Macielak MR, Bonassar LJ, Härtl R. Spine (Phila Pa 1976). 2014 Feb 1;39(3):198-206. doi: 10.1097/BRS.0000000000000103.

Quantitative characterization of mesenchymal stem cell adhesion to the articular cartilage surface. Hung BP, Babalola OM, Bonassar LJ. J Biomed Mater Res A. 2013 Dec;101(12):3592-8. doi: 10.1002/jbm.a.34647. Epub 2013 Jun 7.

Spatial periodicity in growth plate shear mechanical properties is disrupted by vitamin D deficiency. Sevenler D, Buckley MR, Kim G, van der Meulen MC, Cohen I, Bonassar LJ. J Biomech. 2013 Jun 21;46(10):1597-603. doi: 10.1016/j.jbiomech.2013.04.023. Epub 2013 May 21.

High density type I collagen gels for tissue engineering of whole menisci. Puetzer JL, Bonassar LJ. Acta Biomater. 2013 May 10. doi:pii: S1742-7061(13)00234-1. 10.1016/j.actbio.2013.05.002. [Epub ahead of print] PMID: 23669622

High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities. Reiffel AJ, Kafka C, Hernandez KA, Popa S, Perez JL, Zhou S, Pramanik S, Brown BN, Ryu WS, Bonassar LJ, Spector JA. PLoS One. 2013;8(2):e56506. doi: 10.1371/journal.pone.0056506. Epub 2013 Feb 20

The Effect of IGF-I on Anatomically-shaped Tissue Engineered Menisci. Puetzer, JL, Brown, B, Ballyns, JJ, Bonassar, LJ. Tissue Eng Part A. 2013 [Epub ahead of print]

Anatomic variation of depth-dependent mechanical properties in neonatal bovine articular cartilage. Silverberg JL, Dillavou S, Bonassar LJ, Cohen I. J Orthop Res. 2012 Dec 31. doi: 10.1002/jor.22303. [Epub ahead of print]

Tissue-engineered total disc replacement: final outcomes of a murine caudal disc in vivo study. James AR, Bowles RD, Gebhard HH, Bonassar LJ, Härtl R. Evid Based Spine Care J. 2011 Nov;2(4):55-6. doi: 10.1055/s-0031-1274758.

Cell(MC3T3-E1)-printed poly(ϵ-caprolactone)/alginate hybrid scaffolds for tissue regeneration. Lee H, Ahn S, Bonassar LJ, Kim G. Macromol Rapid Commun. 2013 Jan 25;34(2):142-9. doi: 10.1002/marc.201200524. Epub 2012 Oct 12.

Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds. Hockaday LA, Kang KH, Colangelo NW, Cheung PY, Duan B, Malone E, Wu J, Girardi LN, Bonassar LJ, Lipson H, Chu CC, Butcher JT. Biofabrication. 2012 Sep;4(3):035005. doi: 10.1088/1758-5082/4/3/035005. Epub 2012 Aug 23.

Cells (MC3T3-E1)-laden alginate scaffolds fabricated by a modified solid-freeform fabrication process supplemented with an aerosol spraying.
Ahn S, Lee H, Bonassar LJ, Kim G. Biomacromolecules. 2012 Sep 10;13(9):2997-3003. doi: 10.1021/bm3011352. Epub 2012 Aug 30.

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior.
Mason BN, Starchenko A, Williams RM, Bonassar LJ, Reinhart-King CA. Acta Biomater. 2013 Jan;9(1):4635-44. doi: 10.1016/j.actbio.2012.08.007. Epub 2012 Aug 16.

Properties of cartilage engineered from elderly human chondrocytes for articular surface repair.
Zhao X, Bichara DA, Ballyns FP, Yoo JJ, Ong W, Randolph MA, Bonassar LJ, Gill TJ. Tissue Eng Part A. 2012 Jul;18(13-14):1490-9. doi: 10.1089/ten.TEA.2011.0445. Epub 2012 Jun 5.

The effect of the duration of mechanical stimulation and post-stimulation culture on the structure and properties of dynamically compressed tissue-engineered menisci.
Puetzer JL, Ballyns JJ, Bonassar LJ. Tissue Eng Part A. 2012 Jul;18(13-14):1365-75. doi: 10.1089/ten.TEA.2011.0589. Epub 2012 Apr 26.

Mathematical modeling and frequency gradient analysis of cellular and vascular invasion into integra and strattice: toward optimal design of tissue regeneration scaffolds.
Reiffel AJ, Henderson PW, Krijgh DD, Belkin DA, Zheng Y, Bonassar LJ, Stroock AD, Spector JA. Plast Reconstr Surg. 2012 Jan;129(1):89-99.