Edward Bonnevie has published a paper in the journal Cartilage and a paper in the journal PLoS One.
In this paper, we present a post-traumatic osteoarthritis model that utilizes a spring-loaded impacting device. We show that this device can provide controlled, repeatable insults to the surfaces of articular cartilage and determine mechanical thresholds around which surface cracking may occur in cartilage.
In this paper, we present a framework to more fully understand lubrication by synovial fluid macromolecules. Specifically, we found that two molecules, lubricin and hyaluronic acid, lubricate by distinct mechanisms but also act synergistically. Optimal cartilage lubrication is achieved when the boundary lubricant, lubricin, anchors to the cartilage surface and facilitates the aggregation of the viscous lubricant, hyaluronic acid.
