Bonassar Lab alum Dr. Jenny Puetzer has accepted a position as an Assistant Professor in the Department of Biomedical Engineering at Virginia Commonwealth University. She received her PhD in Biomedical Engineering from Cornell in 2014 and is currently a Whitaker Foundation International Fellow in the laboratory of Prof. Molly Stevens in Imperial College, London. She will finish her postdoctoral studies at the end of 2017 and begin her faculty position at VCU in January 2018. Congratulations, Jenny!
Benjamin Cohen receives a Scientist Award for the TERMIS-AM 2016 Conference. Ben has received this award for his presentation entitled “Full-Scale Tissue Engineered Auricles through Auricular Chondrocyte-Mesenchymal Stem Cell Co-Implantation” discussing his research tissue engineering the human ear.
Mary Clare McCorry was accepted to the American Institute for Molecular and Biological Engineering (AIMBE) FDA Scholars Program at the Center for Devices and Radiological Health (CDRH). This program places distinguished post-doctorates in medical and biological engineering within CDRH to work side-by-side with influential decision makers to inform regulatory policy decisions.
Congrats, Mary Clare!
Work from the Bonassar Lab on 3D printing of cartilage was featured in the Tech News segment of a recent issue of the journal BioTechniques. The feature, entitled “Print on Demand,” describes the work of multiple laboratories using 3D printing for rapid, scalable manufacturing of biological tissues. It details the work of the Bonassar Lab in developing biological inks using alginate and collagen to produce cartilage for reconstructive surgery and orthopaedic applications. See BioTechniques article: PRINT ON DEMAND to learn more about our work!
Three members of the Bonassar Lab won awards for presentations at the 2017 meeting of the Orthopaedic Research Society in San Diego, CA. Bonassar lab alum Dr. Eddie Bonnevie won a New Investigator Research Award (NIRA) for his work demonstrating the effects of inhibited cartilage lubrication on chondrocyte apoptosis and mitochondrial dysfunction. PhD student Liz Feeney won a Poster Teaser Presentation Award for her describing the design and functionality of biomimetic cartilage lubricants. PhD student Mary Clare McCorry won 2nd place in the Podium Presentation competition for the Meniscus Section for her work on controlling fiber formation in tissue engineered meniscus implants by manipulating the glucose content of culture media. Congratulations to Eddie, Liz, and Mary Clare!
The Bonassar Group is traveling to the ORS 2017 Annual Meeting to present 6 papers and 10 posters. Mary Clare McCorry is an award semi-finalist for the Meniscus Section, and Dr. Edward Bonnevie is an award semi-finalist for NIRA. Take a look through the meeting program, and come see our work. We hope to see you there!
Rebecca Irwin and Dr. John Kennedy of HSS were awarded a research grant for a project entitled “The Effect of Platelet Rich Plasma and Tribosupplementation in Osteochondral Lesions Treated with Microfracture: An in vivo Rabbit Model” from the Arthroscopy Association of North America (AANA). This work will test the hypothesis that decreased friction improves integration of repaired cartilage with native host tissue by decreasing shear stresses during repaired cartilage development. If tribosupplemntation aids in cartilage repair, this information could alter the clinical approach to osteochondral lesion repair and directly impact treatment options for patients.
Bonassar Lab alum Dr. Kirk Samaroo recently had his manuscript accepted by the journal Biotribology:
The paper describes the development of a library of brush-copolymers designed to lubricate cartilage. These new biomaterials mimic structure of the lubricating properties of the glycoprotein lubricin, which serves as the primary boundary lubricant for articular cartilage. The polymers are composed polyethylene glycol (PEG) side chains grafted to a poly(acrylic acid) (pAA) backbone, similar to the oligosaccharides that decorate the core protein lubricin. When attached to gold surfaces, all of these new brush co-polymers lubricated cartilage, with the most efficient configuration lowering coefficient of friction by a factor of 2. This work was conducted in collaboration with Prof. David Putnam of the Meinig School of Biomedical Engineering at Cornell, Dr. Mingchee Tan, an alum of the Putnam Lab, and Dr. Delphine Gourdon of the University of Ottawa. Dr. Samaroo is the co-founder of and CSO of Dynamic Boundaries, Inc., an Ithaca-based startup company that is developing biomimetic lubricants for the treatment of arthritis.
Jill Middendorf published the following paper in the Journal of Orthopaedic Research:
Tissue engineered cartilage is a widely recognized method for the repair of focal cartilage defects. These cartilage constructs must provide mechanical support and function in the joint. To fully understand the function of cartilage constructs and to meet recommendations provided by the FDA, multiple mechanical properties of engineered cartilage constructs need to be measured. Although many studies have identified the compressive properties, few have examined the frictional and shear properties. This study is the first study to perform three mechanical tests (compression, friction, and shear) on a human tissue engineered cartilage implant. Results show compressive and frictional properties improve with increased construct maturation, while shear properties remain constant. This study suggests the various mechanical and biological properties of tissue engineered cartilage improve at different rates, indicating thorough mechanical evaluation of tissue engineered cartilage is critical to understanding the performance of repaired cartilage.
Bonassar Lab alum Dr. Nizeet Aguilar recently had her manuscript “Customized Biomaterials to Augment Chondrocyte Gene Therapy” accepted by the journal Acta Biomateriala. The paper describes the development of a modified alginate biomaterial designed to bind insulin-like growth factor-I (IGF-I). This material was designed to work synergistically with chondrocytes transfected to overexpress IGF-I, enabling control of both the production and availability of the growth factor. This combined approach proved highly effective, enhancing matrix production by chondrocytes by almost 20-fold. This work was conducted collaboration with Drs. Stephen Trippel and Shuiliang Shi, both of the Indiana School of Medicine, where Dr. Aguilar is pursuing her postdoctoral studies. Congratulations, Nizeet!