Rebecca Irwin Receives her PhD in Biomedical Engineering

Rebecca Irwin passed her B Exam and received her PhD in Biomedical Engineering. Her doctoral thesis was entitled “Imaging the microscope mechanical response of articular cartilage in early stage osteoarthritis treatments”. Rebecca’s thesis work examined the mechanical effects of early OA treatments on articular cartilage using microscale confocal elastography. Congrats, Rebecca!

Liz Feeney Receives her PhD in Biomedical Engineering

Liz Feeney passed her B Exam and received her PhD in Biomedical Engineering. Her doctoral thesis was entitled “Synovial Fluid Lubrication in Disease: Characterization, Mechanisms, & Therapy” and focused on applying tribological principles to understand variations in synovial fluid composition between various phenotypes of osteoarthritis. Congrats, Liz!

Rebecca Irwin Publishes a Paper in Osteoarthritis and Cartilage

Congratulations to Rebecca Irwin and her co-authors on their accepted manuscript in Osteoarthritis and Cartilage titled “Distinct tribological endotypes of pathological human synovial fluid reveal characteristics biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage.” This study identified tribological endotypes of synovial fluid from arthritic patients. Specifically, tribological endotypes were distinguished by elevated friction coefficients, cartilage tissue strains, and lubricating efficacy of viscosupplements. Across all synovial fluid samples, aberrant lubricating behavior was associated with changes in lubricin and inflammatory biomarkers (polymorphonuclear neutrophil composition and IL-8). Previous studies have identified synovial fluid phenotypes based on expression of biomarkers, but this is the first study to link such compositional features to lubricating function. Further, the variability in response of these phenotypes to viscosupplementation may give new insight into how biomarker expression can be used to inform treatment for arthritis patients.

Introduction to the Bonassar Lab

Hello prospective PhD students! We, at the Bonassar lab, created this short video to give you a look into the daily activities that go on within our lab. If you have any further questions please feel free to reach out to any of us via email. We hope to see you in the Fall!

 

 

Bonassar Lab Travels to 2020 ORS Annual Meeting

The Bonassar lab is traveling to the 2020 ORS Annual Meeting in Phoenix, Arizona. We will be presenting the following abstracts:

Steven Ayala is presenting: Spatial Pattern Of Cellular Response Of Articular Cartilage To Mechanical Injury Depends On Impact Magnitude, Poster #0608

Tianyu Gao is Presenting: Non-Destructive Spatial Mapping of GAG Loss in Articular Cartilage Using Confocal Raman Spectroscopy, Poster #1514

Rebecca Irwin is presenting: Microscale Compositional Mapping Predicts Local Strains Across Interface of Cartilage Repair from an Eight Month Equine Model, Poster #0387

Stephen Sloan Receives his PhD in Biomedical Engineering

Stephen Sloan passed his B Exam and received his PhD in Biomedical Engineering. His doctoral thesis was entitled “Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration” and focused on developing and optimizing a treatment for intervertebral disc degeneration by using materials that repair both the annulus fibrosus and nucleus pulposus in the IVD. Congrats, Stephen!

Rebecca Irwin Publishes a Paper in PLOS ONE

Congratulations to Rebecca and her co-authors on their accepted manuscript in PLOS ONE titled “The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair.” This study investigated how allogeneic and autologous sources affected the mechanical properties of clinically available fibrin sealants for cartilage repair. These results are aimed at translation to clinical practice and will help orthopedic surgeons optimize sealants for articular cartilage repair.
 

 

Stephen Sloan Wins Award for Outstanding Scientific Research at ORS PSRS Meeting

Stephen Sloan won a Trainee Podium Award for Outstanding Scientific Research at the Orthopaedic Research Society/Philadelphia Spine Research Symposium for his paper entitled “Imaging the Local Biochemical Content of the Intervertebral Disc using Fourier Transform Infrared Microscopy.” His work used advanced microscopy tools to better measure the degenerative changes that occur in intervertebral discs after herniation. He found that this new technique was more sensitive than traditional histology for measuring compositional changes in the outer portion of the intervertebral disc, known as the annulus fibrosus.

Results from this study can be used to better understand the process of disc degeneration and to better evaluate new therapies.  Congratulations to Stephen and his co-authors!

Bonassar Lab Travels to 2019 BMES Annual Meeting

The Bonassar lab is traveling to the 2019 BMES Annual Meeting in Philadelphia, Pennsylvania. We will be presenting the following abstracts:

Steven Ayala is presenting Spatial Pattern of Cellular Response of Articular Cartilage to Mechanical Injury Depends on Impact Magnitude on Friday, October 18, 2019 at 8:00 AM

Leigh Slyker is presenting Mechanical Performance of Collagen Gels is Dependent on Purity, lower case Greek alpha1/lower case Greek alpha2 Ratio, and Telopeptides on Friday, October 18, 2019 at 9:00AM

Marianne Lintz is presenting Tissue Engineered IVD’s Show Enhanced Collagen Alignment At Sub-Physiologic Levels Of Glucose on Friday, October 18, 2019 at 9:30AM

Cassie Gologorsky is presenting Depth-dependent Shear Modulus of TMJ Condylar Cartilage Varies with Anatomic Location on Friday, October 18, 2019 at 9:30AM

Jared Matthews is presenting Feasibility of a Low-cost Electrical Impedance Spectrometer for Investigating Cell-Saline Suspensions on Saturday, October 19, 2019 at 9:30AM

Congratulations to all of our presenting students!