Christopher DiDomenico published a paper in the Journal of Biomechanical Engineering entitled, “The Effect of Antibody Size and Mechanical Loading on Solute Diffusion through the Articular Surface of Cartilage.”
Due to the heterogeneous nature of articular cartilage tissue, penetration of potential therapeutic molecules for osteoarthritis (OA) through the articular surface is complex, with many factors that affect transport of these solutes within the tissue. Therefore, the goal of work is to investigate how the size of antibody variants, as well as application of cyclic mechanical loading, affect solute transport within healthy cartilage tissue. Ultimately, solutes of this size do not diffuse uniformly, nor are convected uniformly, through the depth of the cartilage tissue. This research potentially holds great clinical significance to discover ways of further optimizing transport into cartilage and lead to effective antibody-based treatments for OA.
