Alexander Boys and Mary Clare McCorry Publish an Article in MRS Communications

Alexander Boys and Mary Clare McCorry published an article in MRS Communications.

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces 

This article reviews current strategies for tissue engineering soft tissue-to-bone interfaces, specifically the enthesis of tendons, ligaments, and the meniscus. The tissue engineering process is broken down into three sections: Materials processing methods, Cellular contributions, and Biochemical factors. These processes can be concurrently applied to produce a tissue engineered construct. Such a construct then undergoes maturation by stimulation through mechanical and chemical means before developing into an implantable construct. The review culminates in an outline of future challenges for the interfacial tissue engineering field.

Bonassar Lab Travels to the 2017 BMES Annual Meeting

The Bonassar lab is traveling to the 2017 BMES Annual Meeting in Phoenix, Arizona. We will be presenting four abstracts. See below for details:
 
Jorge Santiago is presenting Total Cervical Disc Replacement with Tissue-Engineered Intervertebral Discs Assisted by Resorbable Stabilization System in a Canine Spine Model on Thursday, October 12 at 8:15AM
 
Ben Cohen is presenting Extensively Passaged Human Auricular Chondrocytes Retain the Capacity to Generate Auricular Cartilage In Vivo on Thursday, October 12 at 3:45PM
 
In collaboration with Dr. Jason Spector, work from Ben Cohen and Dr. Bonassar will be presented Custom 3D-Printed External Biocompatible Cage Mitigates Contraction During Maturation of Human Auricular Cartilage Scaffolds on Thursday, October 12 at 4:15PM
 
Stephen Sloan is presenting Cell-Laden Annulus Fibrosus Repair in an In Vivo Ovine Lumbar Spine Model on Thursday, October 12 at 4:15PM

Liz Feeney Receives her M.S. in Biomedical Engineering

Liz Feeney passed her A Exam and received her M.S. in Biomedical Engineering. Congrats, Liz!

Benjamin Cohen Receives 2nd Place in Cornell University 6th Stem Cell Symposium

Benjamin Cohen received the 2nd place award in the Poster Competition at the Cornell University 6th Stem Cell Symposium for his poster “Tissue Engineering the Human Auricle by Auricular Chondrocyte-Mesenchymal Stem Cell Co-Implantation.” Congratulations, Ben!

Stephen Sloan Publishes an Article in Acta Biomaterialia

Stephen Sloan recently published an article in the journal Acta Biomaterialia entitled: Initial Investigation of Individual and Combined Annulus Fibrosus and Nucleus Pulposus Repair Ex Vivo.

 

Intervertebral disc degeneration affects an estimated 90% of individuals throughout their life, and is a candidate pathology for tissue engineered repair. The current standard of clinical care reduces spinal articulation and leads to further degeneration along the spine, hence great interest in a regenerative medicine therapy. Lit- erature studies focused on biomaterial repair strategies for treating degenerated discs have partially restored native disc function, however no studies have reported the use of combined therapies to address multiple aspects of disc degeneration. This initial investigation screened injectable biomaterial repair strategies ex vivo, and through complementary outcome measures showed a combined therapy restores disc function better than individual approaches. This study is the first of its kind to address multiple aspects of disc degeneration, using clinically-oriented biomaterials in a well-established animal model.

Nicole Diamantides Publishes a Paper in Biofabrication

Nicole Diamantides published a paper in Biofabrication entitled, Correlating rheological properties and printability of collagen bioinks: the effects of riboflavin photocrosslinking and pH.

Collagen has shown promise as a bioink for extrusion-based bioprinting, but further development of new collagen bioink formulations is necessary to improve their printability. The goal of this work was to determine the effects of riboflavin photocrosslinking and pH on collagen bioink rheology before, during, and after gelation and directly correlate these findings to the printability of each bioink formulation.  We found that riboflavin photocrosslinking and pH levels above physiologic resulted in improved collagen bioink printability and that printability was most strongly correlated with rheological properties of the bioink during extrusion.  These findings will allow for the more rapid screening of new collagen bioink formulations.

Christopher DiDomenico Publishes a Paper in the Journal of Biomechanical Engineering

Christopher DiDomenico published a paper in the Journal of Biomechanical Engineering entitled, “The Effect of Antibody Size and Mechanical Loading on Solute Diffusion through the Articular Surface of Cartilage.”

Due to the heterogeneous nature of articular cartilage tissue, penetration of potential therapeutic molecules for osteoarthritis (OA) through the articular surface is complex, with many factors that affect transport of these solutes within the tissue. Therefore, the goal of work is to investigate how the size of antibody variants, as well as application of cyclic mechanical loading, affect solute transport within healthy cartilage tissue. Ultimately, solutes of this size do not diffuse uniformly, nor are convected uniformly, through the depth of the cartilage tissue. This research potentially holds great clinical significance to discover ways of further optimizing transport into cartilage and lead to effective antibody-based treatments for OA.

Prof. Bonassar and Dr. Härtl Publish a Book on Intervertebral Disc Repair

Prof. Larry Bonassar and long-time collaborator Dr. Roger Härtl, Professor of Neurosurgery and Chief of Spinal Surgery at Weill Cornell Medical, are the editors of a newly published book titled “Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians.” The book summarizes current biologically based approaches to treatment of degenerative disc disease, including the development of biomaterials and engineered tissues for the repair and regeneration of soft tissues in the spine.  The book includes 21 chapters authored by more than 60 international experts in the fields of orthopaedics, neurosurgery, biomechanics, biomaterials, and tissue engineering. The book is published through Thieme Publishing (New York) and will be officially released on July 12, 2017.  Print and electronic copies can be ordered through Amazon.

Mary Clare McCorry Receives her PhD in Biomedical Engineering

Mary Clare McCorry passed her B Exam and received her PhD in Biomedical Engineering. Congrats, Mary Clare!

Alexander Boys Receives a Travel Award from at the ICCBMT

Alexander Boys received a ICCBMT Travel Award at the International Conference on the Chemistry and Biology of Mineralized Tissue (ICCBMT). Congrats, Alex!